GTX31419
CIITA antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX31419
- Zusätzliche Namen:
- class II major histocompatibility complex transactivator , C2TA , CIITAIV , MHC2TA , NLRA
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- CIITA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CIITA.The immunogen is located within amino acids 120 - 170 of CIITA.
- Uniprot:
- P33076
- Synonyme:
- C2TA;CIITAIV;MHC class II transactivator;MHC class II transactivator type I;MHC class II transactivator type III;MHC2TA;NLR family, acid domain containing;NLRA;nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
- Weitere Details:
- This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
- Versandbedingungen:
- Blue Ice