GTX31313-PEP
Presenilin 1 blocking peptide
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX31313-PEP
- Zusätzliche Namen:
- Presenilin 1 , Acninv3 , Ad3 , Fad , Ps-1 , Ps1 , S182 , Psen1
- Anwendung:
- Neutralisation
- Konzentration:
- 200 ug/ml
- Physischer Zustand:
- Liquid
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Genetex
- Buffer:
- PBS, 0.1% BSA, 0.02% Sodium azide.
- Immunogen:
- presenilin 1
- Spezies:
- Human
- Synonyme:
- ACNINV3;AD3;FAD;presenilin-1;PS-1;PS1;S182
- Weitere Details:
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
- Versandbedingungen:
- Dry Ice