GTX30104
ATM antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX30104
- Zusätzliche Namen:
- ATM serine/threonine kinase , AT1 , ATA , ATC , ATD , ATDC , ATE , TEL1 , TELO1
- Anwendung:
- ELISA, Flow Cytometry, WB, IHC-P, IF, ICC, IP
- Konzentration:
- 2.5 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 50% Glycerol, 0.05% Sodium azide.
- Immunogen:
- A fragment of the human ATM protein corresponding to the C-terminus (within the last third of the protein sequence). [UniProt# Q13315]
- Uniprot:
- Q13315
- Synonyme:
- A-T mutated;AT mutated;AT1;ATA;ataxia telangiectasia mutated;ATC;ATD;ATDC;ATE;serine-protein kinase ATM;TEL1;TEL1, telomere maintenance 1, homolog;TELO1
- Weitere Details:
- The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Versandbedingungen:
- Blue Ice