GTX29665
ILP2 peptide
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX29665
- Zusätzliche Namen:
- Baculoviral Iap Repeat Containing 8 , Ilp-2 , Ilp2 , Rnf136 , Hilp2 , Birc8
- Anwendung:
- Neutralisation
- Konzentration:
- 0.20 mg/ml
- Physischer Zustand:
- Liquid
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Genetex
- Buffer:
- PBS, 0.1% BSA, 0.02% Sodium azide.
- Immunogen:
- baculoviral IAP repeat containing 8
- Spezies:
- Human
- Synonyme:
- baculoviral IAP repeat-containing protein 8;hILP2;IAP-like protein 2;ILP-2;ILP2;inhibitor of apoptosis-like protein 2;RNF136;testis-specific inhibitor of apoptosis
- Weitere Details:
- Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
- Versandbedingungen:
- Dry Ice