GTX28391
BACE2 peptide
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX28391
- Zusätzliche Namen:
- Beta-Secretase 2 , Aeplc , Alp56 , Asp1 , Asp21 , Bae2 , Cda13 , Ceap1 , Drap , Bace2
- Anwendung:
- Neutralisation
- Konzentration:
- 0.20 mg/ml
- Physischer Zustand:
- Liquid
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Genetex
- Buffer:
- PBS, 0.1% BSA, 0.02% Sodium azide.
- Immunogen:
- beta-site APP-cleaving enzyme 2
- Spezies:
- Human
- Synonyme:
- 56 kDa aspartic-like protease;AEPLC;ALP56;ASP1;ASP21;aspartyl protease 1;BAE2;beta-secretase 2;beta-site amyloid beta A4 precursor protein-cleaving enzyme 2;beta-site APP-cleaving enzyme 2;CDA13;CEAP1;Down syndrome region aspartic protease;DRAP;memapsin-1;membrane-associated aspartic protease 1;SLCO3A1/BACE2 fusion;theta-secretase;transmembrane aspartic proteinase Asp1
- Weitere Details:
- Accumulation of the abeta in plaques in the cerebral cortex is a critical event in the pathogenesis of Alzheimers disease. Abeta peptide is generated by proteolytic cleavage of the b-amyloid protein precursor(APP) at by secretases. BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at b-site and at a different site within Ab. BACE2 locates on chromosome 21q22.3, the so-called Down critical region, suggesting that BACE2 and Ab may also contribute to the pathogenesis of Down syndrome.
- Versandbedingungen:
- Dry Ice