GTX27028
HDAC1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX27028
- Zusätzliche Namen:
- histone deacetylase 1 , GON-10 , HD1 , KDAC1 , RPD3 , RPD3L1
- Anwendung:
- WB, IHC-P, IF, ICC, IP
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 15mM Sodium azide.
- Immunogen:
- synthetic peptide corresponding to amino acids 466-482 of human and mouse HDAC1.
- Uniprot:
- Q13547
- Synonyme:
- GON-10;HD1;histone deacetylase 1;KDAC1;reduced potassium dependency, yeast homolog-like 1;RPD3;RPD3L1
- Weitere Details:
- Reversible acetylation of highly conserved lysine residues in N-terminal tail domains of core histones plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation is a dynamic process determined by the net activities of histone acetyltransferases (HATs) and the competing enzymes histone deacetylases (HDACs) (ref 3). Histone deacetylases activities were often, but not always, associated with transcriptional repression and nucleosomal condensations (ref 6,7). Recruitment of the multiprotein complexes to promoter sites occurs by many sequence specific DNA-binding proteins such as unliganded nuclear hormone receptors, DP1-E2F, YY1 and Rb family of transcription factors, transcriptional repressors and tumor suppressors (e.g. BRCA1). Aberrant recruitment of HDACs by certain oncoproteins may occur in certain neoplastic diseases.(ref 11)
- Versandbedingungen:
- Blue Ice