GTX26558
NFYA antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX26558
- Zusätzliche Namen:
- nuclear transcription factor Y subunit alpha , CBF-A , CBF-B , HAP2 , NF-YA
- Anwendung:
- ChIP, ELISA, WB
- Konzentration:
- 0.6 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- 20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.
- Immunogen:
- Synthetic NF-Y (A subunit) peptide corresponding to a region near the N-terminus of the human protein conjugated to KLH.
- Uniprot:
- P23511
- Synonyme:
- CAAT box DNA-binding protein subunit A;CAAT-box DNA binding protein subunit A;CBF-A;CBF-B;CCAAT-binding transcription factor subunit B;HAP2;HAP2 CCAAT-binding protein;NF-YA;nuclear transcription factor Y subunit A;nuclear transcription factor Y subunit alpha;nuclear transcription factor Y, alpha;Transcription factor NF-Y, A subunit
- Weitere Details:
- The Y box is a CCAAT box that is bound by the heteromeric DNA binding protein, NF-Y (also known as CBF and CP1). Unlike the transcription factors C/EBP and CTF/NF1, which also bind CCAAT-like sequences, NF-Y exhibits a strict binding requirement for this pentanucleotide sequence. Binding sites for this factor have been described for nearly 30% of all eukaryotic genes. Y/CCAAT sequences were frequently observed in the promoter-proximal sequences. NF-Y is composed of 3 separate subunits (A, B and C) each of which is required for DNA binding. Each subunit has remained highly conserved throughout evolution. In fact, homologous yeast subunits can substitute for mammalian NF-Y in DNA-binding assays. The conserved core sequences of NF-YB and NF-YC contain a 70 aa region similar to the histone fold motif of nucleosomes H2A and H2B. The unique structure and evolutionary conservation of this transcription factor suggests that it plays a fundamental role in the readout of eukaryotic genetic information.
- Versandbedingungen:
- Blue Ice