GTX26243
MTA2 peptide
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX26243
- Zusätzliche Namen:
- Metastasis Associated 1 Family Member 2 , Mta1L1 , Pid , Mta2
- Anwendung:
- Neutralisation
- Konzentration:
- 0.20 mg/ml
- Physischer Zustand:
- Liquid
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Genetex
- Buffer:
- PBS, 0.1% BSA, 0.02% Sodium azide.
- Immunogen:
- metastasis associated 1 family, member 2
- Spezies:
- Human
- Synonyme:
- metastasis -associated gene 1-like 1;metastasis associated gene family, member 2;metastasis-associated 1-like 1;metastasis-associated protein 2;metastasis-associated protein MTA2;MTA1-L1 protein;MTA1L1;p53 target protein in deacetylase complex;PID
- Weitere Details:
- The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in the p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex. PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis. PID/MTA2 is ubiquitously expressed in human tissues.
- Versandbedingungen:
- Dry Ice