GTX25668
FE65 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX25668
- Zusätzliche Namen:
- amyloid beta (A4) precursor protein-binding, family B, member 1 , Fe65 , Rir
- Anwendung:
- Flow Cytometry, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Mouse
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.1% BSA, 0.05% Sodium azide.
- Immunogen:
- Synthetic Peptide: P(352) Q E E E K L S Q R N A N P G I K C(369)
- Uniprot:
- Q9QXJ1
- Synonyme:
- amyloid-beta A4 precursor protein-binding family B member 1;Fe65;Protein Fe65;Rir
- Weitere Details:
- The major transcript of the Fe65 gene is a neuron-specific mRNA that encodes a nuclear protein whose amino-terminal domain strongly activates the transcription of reporter genes. Fe65 has been implicated in a regulatory and cell signaling mechanism because it contains two different motifs involved in protein binding; a WW domain (a variant of Src homology 3 domains) and a phosphotyrosine interaction domain (PID). Interestingly, the PID domain binds to the same motif present in the conserved cytoplasmic domains of the beta PP and beta PP-like proteins. RNA analyses revealed that Fe65 is predominantly expressed in the brain and in the regions most affected by Alzheimer's disease-associated neuropathology.
- Versandbedingungen:
- Blue Ice