GTX25482
Rac1 + CDC42 (phospho Ser71) antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX25482
- Anwendung:
- Flow Cytometry, WB, IHC-P
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 0.1% BSA, 50% Glycerol, 0.05% Sodium azide.
- Immunogen:
- The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human Rac1-protein that contains serine 71. The sequence is conserved in human and mouse Rac 1, 2, and 3, and cdc42 human, mouse, rat, dog and frog.
- Weitere Details:
- RAC, Cdc 42 and Rho A, B, and C are members of a small RhoGTPase family that bind and hydrolyze GTP. GTP bound RAC 1 and cdc 42 play a pivotal role in controlling cell shape, adhesion, growth and transformation. Active Rac 1 is implicated in regulating serum response element (SRE), NFAT 1 and nuclear factor kappa B (NF kappa B) transcription activities. Activated RAC 1 and Cdc 42 bind and activate PAK 1, which in turn activates key downstream signaling proteins including MEKK 1 and JNK. RAC 1 and Cdc 42 are phosphorylated on serine 71, a putative Akt site located between the protein binding domain and GTP binding domain. Phosphorylation of RAC 1 on serine 71 regulates its GTP binding and GTPase activity.
- Versandbedingungen:
- Blue Ice