GTX25272
USP20 antibody, C-term
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX25272
- Zusätzliche Namen:
- ubiquitin specific peptidase 20 , LSFR3A , VDU2 , hVDU2
- Anwendung:
- WB, IHC-P
- Konzentration:
- 0.50 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Ammonium Sulfate Precipitated; Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Goat
- Reaktivitäten:
- Human
- Buffer:
- TBS, 0.5% BSA, 0.02% Sodium azide.
- Immunogen:
- Peptide with sequence C-HGEQKIEAETRAV, from the C Terminus of the protein sequence according to NP_006667.3.
- Uniprot:
- Q9Y2K6
- Synonyme:
- deubiquitinating enzyme 20;hVDU2;LSFR3A;pVHL-interacting deubiquitinating enzyme 2;ubiquitin carboxyl-terminal hydrolase 20;ubiquitin thioesterase 20;ubiquitin thiolesterase 20;ubiquitin-specific-processing protease 20;VDU2;VHL-interacting deubiquitinating enzyme 2
- Weitere Details:
- This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]
- Versandbedingungen:
- Blue Ice