E2F1 antibody [KH95]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX24070
Zusätzliche Namen:: E2F transcription factor 1 , E2F-1 , RBAP1 , RBBP3 , RBP3
Anwendung:: ChIP, WB, IHC-P, IP
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Unpurified
Lagerbedingungen:: 2-8[o]C
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: Ascites, 0.09% Sodium azide.
Immunogen:: BALB/C mice were immunized with a recombinant human E2F-1 protein.
Klon:: KH95
Uniprot:: Q01094
Synonyme:: E2F-1;PBR3;PRB-binding protein E2F-1;RBAP-1;RBAP1;RBBP-3;RBBP3;RBP3;retinoblastoma-associated protein 1;retinoblastoma-binding protein 3;transcription factor E2F1
Weitere Details:: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

Versandbedingungen:: Blue Ice