PC2 antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX23533
Zusätzliche Namen:: proprotein convertase subtilisin/kexin type 2 , 6330411F23Rik , AI839700 , Nec-2 , Nec2 , PC2 , Phpp-2 , SPC2
Anwendung:: WB, IF, ICC
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human, Mouse
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: PBS, 0.1% BSA, 0.05% Sodium azide.
Immunogen:: Synthetic peptide corresponding to residues E(622) L D E A V E R S L Q S I L R K N(638) of mouse PC2.
Uniprot:: P21661
Synonyme:: 6330411F23Rik;AI839700;KEX2-like endoprotease 2;Nec;NEC 2;Nec-;Nec-2;Nec2;neuroendocrine convertase 2;PC;PC2;Php;Phpp-2;prohormone convertase 2;proprotein convertase 2;SP;SPC2
Weitere Details:: The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.

Versandbedingungen:: Blue Ice