GTX23344
SynGAP antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX23344
- Zusätzliche Namen:
- synaptic Ras GTPase activating protein 1 homolog (rat) , Gm1963 , Syngap
- Anwendung:
- Flow Cytometry, IHC, WB, IHC-P, IF, ICC, IP
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Rat
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.1% BSA, 0.05% Sodium azide.
- Immunogen:
- GST fusion protein of a recombinant fragment, residues 947-1167, of rat SynGAP.
- Uniprot:
- F6SEU4
- Synonyme:
- Gm1963;neuronal RasGAP;ras GTPase-activating protein SynGAP;ras/Rap GTPase-activating protein SynGAP;Sy;synaptic Ras GTPase-activating protein 1;synaptic Ras-GAP 1;Syngap
- Weitere Details:
- This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous mutations result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016]
- Versandbedingungen:
- Blue Ice