RANBP2 antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX22938
Zusätzliche Namen:: RAN binding protein 2 , ADANE , ANE1 , IIAE3 , NUP358 , TRP1 , TRP2
Anwendung:: IHC, WB, IHC-Fr
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Bovine, Human
Buffer:: PBS, 0.1% BSA, 0.05% Sodium azide.
Immunogen:: Synthetic peptide corresponding to residues M(1) R R S K A D V E R Y I A S V Q G S(18) of human RanBP2.
Uniprot:: P49792
Synonyme:: 358 kDa nucleoporin;acute necrotizing encephalopathy 1 (autosomal dominant);ADANE;ANE1;E3 SUMO-protein ligase RanBP2;E3 SUMO-protein transferase RanBP2;IIAE3;nuclear pore complex protein Nup358;nucleoporin 358;nucleoporin Nup358;NUP358;P270;ran-binding protein 2;transformation-related protein 2;TRP1;TRP2
Weitere Details:: RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]

Versandbedingungen:: Blue Ice