GTX22096
Cyclin B1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX22096
- Zusätzliche Namen:
- cyclin B1 , CCNB
- Anwendung:
- ELISA, WB, IHC-P, IP
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Unpurified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- Filtered-steriled serum, 0.01% Sodium azide.
- Immunogen:
- Full length fusion protein corresponding to the human gene.
- Uniprot:
- P14635
- Synonyme:
- CCNB;G2/mitotic-specific cyclin-B1
- Weitere Details:
- In mammals, cyclin B associates with inactive p34 cdc2 which facilitates phosphorylation of p34 cdc2 at aa 14 Thr and 15 Tyr. This maintains the inactive state until the end of G2 phase. The inactive cyclin B p34 cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34 cdc2 rendering the complex active at the G2 / M boundary. This mitotic kinase complex remains active until the metaphase / anaphase transition when cyclin B is degraded. This degradation process is ubiquitin dependent and is necessary for the cell to exit mitosis. Therefore, cyclin B p34 cdc2 plays a critical role in G2 to M transition.
- Versandbedingungen:
- Blue Ice