p53 (phospho Ser15) antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX21431
Zusätzliche Namen:: tumor protein p53 , BCC7 , BMFS5 , LFS1 , P53 , TRP53
Anwendung:: ELISA, IHC, WB, IHC-P, IF, ICC, IP
Konzentration:: 0.5 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: PBS, 0.5% BSA, 30% Glycerol, 0.01% Thimerosal.
Immunogen:: Synthetic phospho-peptide surrounding amino acid Ser 15 of human p53.
Uniprot:: P04637
Synonyme:: antigen NY-CO-13;BCC7;BMFS5;cellular tumor antigen p53;LFS1;mutant tumor protein 53;P53;p53 tumor suppressor;phosphoprotein p53;transformation-related protein 53;TRP53;tumor protein 53;Tumor suppressor p53;tumor supressor p53
Weitere Details:: The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNA-PK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage.