GTX17498
CHCHD2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX17498
- Zusätzliche Namen:
- coiled-coil-helix-coiled-coil-helix domain containing 2 , C7orf17 , MIX17B , MNRR1 , NS2TP , PARK22
- Anwendung:
- ELISA, Flow Cytometry, WB, IHC-P
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified; Protein A Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 0.09% Sodium azide.
- Immunogen:
- A KLH conjugated synthetic peptide between 74-103 amino acids from the Central region of human CHCHD2.
- Uniprot:
- Q9Y6H1
- Synonyme:
- 16.7kD protein;aging-associated gene 10 protein;C7orf17;coiled-coil-helix-coiled-coil-helix domain-containing protein 2;coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial;HCV NS2 trans-regulated protein;mitochondria nuclear retrograde regulator 1;mitochondrial nuclear retrograde regulator 1;MIX17 homolog B;MIX17B;MNRR1;NS2TP;PARK22
- Weitere Details:
- The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
- Versandbedingungen:
- Blue Ice