GTX16462
DAP12 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX16462
- Zusätzliche Namen:
- TYRO protein tyrosine kinase binding protein , DAP12 , KARAP , PLOSL , PLOSL1
- Anwendung:
- WB, IP
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 0.08% Sodium azide.
- Immunogen:
- Recombinant full length protein (Human).
- Uniprot:
- O43914
- Synonyme:
- DAP12;DNAX adaptor protein 12;DNAX-activation protein 12;KAR-associated protein;KARAP;killer-activating receptor-associated protein;PLOSL;PLOSL1;polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy;TYRO protein tyrosine kinase binding protein;TYRO protein tyrosine kinase-binding protein
- Weitere Details:
- This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
- Versandbedingungen:
- Blue Ice