GTX15008
BLNK antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX15008
- Zusätzliche Namen:
- AGM4 , BASH , BLNK , BLNKS , Bcell linker , LY57 , SLP65 , bca , B cell linker
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Mouse
- Aufreinigung:
- Purified
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Buffer:
- PBS, 15mM Sodium azide.
- Immunogen:
- A fusion protein representing amino acids 171-356 of human BLNK.
- Uniprot:
- Q8WV28
- Synonyme:
- AGM4;B cell adaptor containing SH2 domain;B-cell activation;B-cell adapter containing a SH2 domain protein;B-cell adapter containing a Src homology 2 domain protein;B-cell linker protein;BASH;bca;BLNK-S;cytoplasmic adapter protein;LY57;SLP-65;SLP65;Src homology [SH2] domain-containing leukocyte protein of 65 kD;Src homology 2 domain-containing leukocyte protein of 65 kDa
- Weitere Details:
- This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
- Versandbedingungen:
- Blue Ice