GTX14927
Bestrophin antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX14927
- Zusätzliche Namen:
- bestrophin 1 , ARB , BEST , BMD , Best1V1Delta2 , RP50 , TU15B , VMD2
- Anwendung:
- ELISA, IHC, WB, IHC-P, IHC-Fr, IF, ICC, IP
- Konzentration:
- 0.68 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Tris/Glycine, 0.5% BSA, 30% Glycerol, 0.02% Sodium azide.
- Immunogen:
- N-epitope Synthetic peptide corresponding to unique amino acid sequences on human Bestrophin 1 protein.
- Uniprot:
- O76090
- Synonyme:
- ARB;BEST;Best disease;Best1V1Delta2;bestrophin-1;BMD;RP50;TU15B;vitelliform macular dystrophy protein 2;VMD2
- Weitere Details:
- This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]
- Versandbedingungen:
- Blue Ice