c-Met antibody [3i20(25H2)]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX14700
Zusätzliche Namen:: AUTS9 , DFNB97 , HGFR , MET , MET protooncogene, receptor tyrosine kinase , RCCP2 , cMet , hepatocyte growth factor receptor , C-Met , MET proto-oncogene, receptor tyrosine kinase
Anwendung:: IHC, WB, IP
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Unpurified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human, Mouse, Rat
Buffer:: 10mM Sodium HEPES, 150mM NaCl, 0.01% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Synthetic peptide corresponding to residues surrounding Tyr1234 of human Met.
Klon:: 3i20(25H2)
Uniprot:: P08581
Synonyme:: AUTS9;c-Met;DFNB97;hepatocyte growth factor receptor;HGF receptor;HGF/SF receptor;HGFR;proto-oncogene c-Met;RCCP2;scatter factor receptor;SF receptor;tyrosine-protein kinase Met
Weitere Details:: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

Versandbedingungen:: Blue Ice