PD-L1 antibody [10F.9G2]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX14145
Anwendung:: Flow Cytometry, WB, IHC-Fr, IF, ICC, Neutralisation
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Mouse
Aufreinigung:: Protein G Purified
Lagerbedingungen:: 2-8[o]C Do not freeze.
Hersteller:: Genetex
Host:: Rat
Reaktivitäten:: Mouse
Buffer:: Filter-sterilized PBS, no preservatives.
Immunogen:: Mouse CD274
Klon:: 10F.9G2
Uniprot:: Q9EP73
Synonyme:: A530045L16Rik;B7 homolog 1;B7h1;PD-;PDCD1 ligand 1;Pdcd1l;Pdcd1l1;Pdcd1lg1;Pdl1;programmed cell death 1 ligand 1
Weitere Details:: The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]