GTX14003
BRCA1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX14003
- Zusätzliche Namen:
- BRCA1 DNA repair associated , BRCAI , BRCC1 , BROVCA1 , FANCS , IRIS , PNCA4 , PPP1R53 , PSCP , RNF53
- Anwendung:
- WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Chicken/Avian
- Reaktivitäten:
- Human
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- Immunogen Sequence: GI # 6552299, sequence 1395-1454 Recombinant breast cancer 1, early onset isoform 1
- Uniprot:
- P38398
- Synonyme:
- BRCA1/BRCA2-containing complex, subunit 1;BRCAI;BRCC1;breast and ovarian cancer susceptibility protein 1;breast cancer 1, early onset;breast cancer type 1 susceptibility protein;BROVCA1;early onset breast cancer 1;Fanconi anemia, complementation group S;FANCS;IRIS;PNCA4;PPP1R53;protein phosphatase 1, regulatory subunit 53;PSCP;RING finger protein 53;RING-type E3 ubiquitin transferase BRCA1;RNF53
- Weitere Details:
- BRCA1 contains at least two nuclear localization signals and is proposed to be a tumor suppressor protein. It is a serine phosphoprotein that undergoes hyperphosphorylation during late G1 and S phases of the cell cycle and is transiently dephosphorylated early after M phase. BRCA 1 protein alters in a qualitative and quantitative manner during cell cycle progression. The amount of BRCA protein is highest during S phase and remains elevated toward G2 / M, before it declines in early G1 phase. Inherited loss of BRCA 1 function confers an increased susceptibility for both breast and ovarian cancer.
- Versandbedingungen:
- Blue Ice