DNMT3A antibody [64B814.1]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX13887
Zusätzliche Namen:: DNA methyltransferase 3A , MmuIIIA
Anwendung:: Flow Cytometry, WB, IF, ICC
Konzentration:: 0.5 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human, Mouse
Aufreinigung:: Protein G Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human, Mouse
Buffer:: PBS, 0.05% BSA, 0.05% Sodium azide.
Immunogen:: This antibody was raised against bacteria expressed HIS-tag recombinant mouse Dnmt3a.
Klon:: 64B814.1
Uniprot:: O88508
Synonyme:: cysteine methyltransferase DNMT3A;DNA (cytosine-5)-methyltransferase 3A;DNA methyltransferase MmuIIIA;DNA MTase MmuIIIA;MmuIIIA
Weitere Details:: Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.

Versandbedingungen:: Blue Ice