GTX13858
MDC1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX13858
- Zusätzliche Namen:
- mediator of DNA damage checkpoint 1 , NFBD1
- Anwendung:
- WB
- Konzentration:
- 0.5 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Protein G Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 0.2% Gelatin, 0.05% Sodium azide.
- Immunogen:
- This antibody was developed against a synthetic peptide corresponding to amino acids 871-888 (RQESDKNGESASPERDRE) of human NFBD1.
- Uniprot:
- Q14676
- Synonyme:
- homologue to Drosophila photoreceptor protein calphotin;mediator of DNA damage checkpoint protein 1;NFBD1;nuclear factor with BRCT domains 1
- Weitere Details:
- The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq]
- Versandbedingungen:
- Blue Ice