DFFB antibody [36A349]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX13592
Zusätzliche Namen:: DNA fragmentation factor subunit beta , CAD , CPAN , DFF-40 , DFF2 , DFF40
Anwendung:: WB
Konzentration:: 0.5 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein G Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: Anti-DFFB monoclonal antibody was raised against a peptide corresponding to amino acids 205 to 222 of human DFFB.
Klon:: 36A349
Uniprot:: O76075
Synonyme:: CAD;caspase-activated deoxyribonuclease;caspase-activated DNase;caspase-activated nuclease;CPAN;DFF-40;DFF2;DFF40;DNA fragmentation factor 40 kDa subunit;DNA fragmentation factor subunit beta;DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
Weitere Details:: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq]

Versandbedingungen:: Blue Ice