GTX134260
SMAD7 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX134260
- Zusätzliche Namen:
- SMAD family member 7 , CRCS3 , MADH7 , MADH8
- Anwendung:
- WB
- Konzentration:
- 0.77 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human SMAD7. The exact sequence is proprietary.
- Uniprot:
- O15105
- Synonyme:
- CRCS3;hSMAD7;MAD (mothers against decapentaplegic, Drosophila) homolog 7;MAD homolog 8;MADH7;MADH8;mothers against decapentaplegic homolog 7;Mothers against decapentaplegic homolog 8;Mothers against decapentaplegic, drosophila, homolog of, 7;mothers against DPP homolog 8;SMAD family member 7;SMAD, mothers against DPP homolog 7
- Weitere Details:
- The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
- Versandbedingungen:
- Blue Ice