GTX130708
ARID1B antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX130708
- Zusätzliche Namen:
- AT-rich interaction domain 1B , 6A3-5 , BAF250B , BRIGHT , CSS1 , DAN15 , ELD/OSA1 , MRD12 , OSA2 , P250R
- Anwendung:
- WB
- Konzentration:
- 1.32 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human ARID1B. The exact sequence is proprietary.
- Uniprot:
- Q8NFD5
- Synonyme:
- 6A3-5;ARID domain-containing protein 1B;AT rich interactive domain 1B (SWI1-like);AT-rich interactive domain-containing protein 1B;BAF250B;BRG1-associated factor 250b;BRG1-binding protein ELD/OSA1;BRG1-binding protein hELD/OSA1;BRIGHT;CSS1;DAN15;ELD (eyelid)/OSA protein;ELD/OSA1;MRD12;Osa homolog 2;OSA2;P250R;SMARCF2
- Weitere Details:
- Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically.
- Versandbedingungen:
- Blue Ice