GTX130695
DHCR7 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX130695
- Zusätzliche Namen:
- 7-dehydrocholesterol reductase , SLOS
- Anwendung:
- WB, IHC-P
- Konzentration:
- 1.46 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the C-terminus region of human DHCR7. The exact sequence is proprietary.
- Uniprot:
- Q9UBM7
- Synonyme:
- 7-dehydrocholesterol reductase;7-DHC reductase;delta-7-dehydrocholesterol reductase;delta7-sterol reductase;putative sterol reductase SR-2;SLOS;sterol delta-7-reductase;Sterol Delta(7)-reductase;sterol reductase SR-2
- Weitere Details:
- The DHCR7 gene encodes delta-7-sterol reductase (EC 1.3.1.21), the penultimate enzyme of mammalian sterol biosynthesis that converts 7-dehydrocholesterol (7-DHC) to cholesterol. This enzyme removes the C(7-8) double bond introduced by the sterol delta8-delta7 isomerases. In addition, its role in drug-induced malformations is known: inhibitors of the last step of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development (Moebius et al., 1998 [PubMed 9465114]).[supplied by OMIM]
- Versandbedingungen:
- Blue Ice