GTX130493
UPF3B antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX130493
- Zusätzliche Namen:
- UPF3B regulator of nonsense mediated mRNA decay , HUPF3B , MRX62 , MRXS14 , RENT3B , UPF3BP1 , UPF3BP2 , UPF3BP3 , UPF3X , Upf3p-X
- Anwendung:
- WB, IHC-P
- Konzentration:
- 1.27 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human UPF3B. The exact sequence is proprietary.
- Uniprot:
- Q9BZI7
- Synonyme:
- HUPF3B;mental retardation, X-linked 62;MRX62;MRX82;MRXS14;nonfunctional UPF3B regulator of nonsense mediated mRNA decay;nonsense mRNA reducing factor 3B;regulator of nonsense transcripts 3B;RENT3B;up-frameshift suppressor 3 homolog B;up-frameshift suppressor 3 homolog on chromosome X;UPF3 regulator of nonsense transcripts homolog B;UPF3B pseudogene 1;UPF3B pseudogene 2;UPF3B pseudogene 3;UPF3BP1;UPF3BP2;UPF3BP3;Upf3p-X;UPF3X
- Weitere Details:
- This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Versandbedingungen:
- Blue Ice