GTX130181
MRP2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX130181
- Zusätzliche Namen:
- ATP binding cassette subfamily C member 2 , ABC30 , CMOAT , DJS , MRP2 , cMRP
- Anwendung:
- WB
- Konzentration:
- 1.76 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Synthetic peptide encompassing a sequence within the Intracellular domain of human MRP2. The exact sequence is proprietary.
- Uniprot:
- Q92887
- Synonyme:
- ABC30;ATP-binding cassette sub-family C member 2;ATP-binding cassette, sub-family C (CFTR/MRP), member 2;canalicular multidrug resistance protein;canalicular multispecific organic anion transporter 1;CMOAT;cMRP;DJS;MRP2;multidrug resistance-associated protein 2
- Weitere Details:
- The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq]
- Versandbedingungen:
- Blue Ice