GTX130062
Hamartin / TSC1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX130062
- Zusätzliche Namen:
- TSC complex subunit 1 , LAM , TSC
- Anwendung:
- WB, IHC-P, IP
- Konzentration:
- 1.38 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the C-terminus region of human Hamartin / TSC1. The exact sequence is proprietary.
- Uniprot:
- Q92574
- Synonyme:
- hamartin;LAM;truncated hemartin;TSC;tuberous sclerosis 1 protein
- Weitere Details:
- This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018]
- Versandbedingungen:
- Blue Ice