MBD4 antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX129605
Zusätzliche Namen:: methyl-CpG binding domain 4, DNA glycosylase , MED1
Anwendung:: WB, IF, ICC
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: PBS, 20% Glycerol, 0.025% ProClin 300.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human MBD4. The exact sequence is proprietary.
Uniprot:: O95243
Synonyme:: 3,N(4)-ethenocytosine glycosylase;G/5-fluorouracil mismatch glycosylase with biphasic kinetics;G/T mismatch glycosylase;G/U mismatch glycosylase;MED1;methyl-CpG binding domain protein 4;methyl-CpG-binding domain protein 4;methyl-CpG-binding endonuclease 1;methyl-CpG-binding protein MBD4;mismatch-specific DNA N-glycosylase;putative methyl-CpG binding protein
Weitere Details:: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. [provided by RefSeq]

Versandbedingungen:: Blue Ice