GTX129507
TRRAP antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX129507
- Zusätzliche Namen:
- transformation/transcription domain associated protein , PAF350/400 , PAF400 , STAF40 , TR-AP , Tra1
- Anwendung:
- ChIP, WB, IP
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human TRRAP. The exact sequence is proprietary.
- Uniprot:
- Q9Y4A5
- Synonyme:
- 350/400 kDa PCAF-associated factor;DEDDFA;DFNA75;PAF350/400;PAF400;STAF40;TR-AP;Tra1;tra1 homolog;transformation/transcription domain-associated protein
- Weitere Details:
- Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression.
- Versandbedingungen:
- Blue Ice