GTX129355
TORC1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX129355
- Zusätzliche Namen:
- CREB regulated transcription coactivator 1 , MAML2 , MECT1 , Mam-2 , TORC-1 , TORC1 , WAMTP1
- Anwendung:
- WB
- Konzentration:
- 0.9 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 20% Glycerol, 0.025% ProClin 300.
- Immunogen:
- Recombinant protein encompassing a sequence within the N-terminus region of human TORC1. The exact sequence is proprietary.
- Uniprot:
- Q6UUV9
- Synonyme:
- CREB-regulated transcription coactivator 1;Mam-2;MAML2;Mastermind-like protein 2;MECT1;mucoepidermoid carcinoma translocated protein 1;TORC-1;TORC1;transducer of regulated cAMP response element-binding protein (CREB) 1;Transducer of regulated cAMP response element-binding protein 1;WAMTP1
- Weitere Details:
- Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.
- Versandbedingungen:
- Blue Ice