CIITA antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX129022
Zusätzliche Namen:: class II major histocompatibility complex transactivator , C2TA , CIITAIV , MHC2TA , NLRA
Anwendung:: WB
Konzentration:: 1.31 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: PBS, 20% Glycerol, 0.025% ProClin 300.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human CIITA. The exact sequence is proprietary.
Uniprot:: P33076
Synonyme:: C2TA;CIITAIV;MHC class II transactivator;MHC class II transactivator type I;MHC class II transactivator type III;MHC2TA;NLR family, acid domain containing;NLRA;nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
Weitere Details:: This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq]

Versandbedingungen:: Blue Ice