GTX127284
ASXL1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX127284
- Zusätzliche Namen:
- ASXL transcriptional regulator 1 , BOPS , MDS
- Anwendung:
- WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the N-terminus region of human ASXL1. The exact sequence is proprietary.
- Uniprot:
- Q8IXJ9
- Synonyme:
- additional sex combs like 1, transcriptional regulator;additional sex combs like transcriptional regulator 1;Additional sex combs-like protein 1;BOPS;MDS;polycomb group protein ASXL1;putative Polycomb group protein ASXL1
- Weitere Details:
- This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
- Versandbedingungen:
- Blue Ice