TET1 antibody [N3C1]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX124207
Zusätzliche Namen:: tet methylcytosine dioxygenase 1 , CXXC6 , LCX , bA119F7.1
Anwendung:: ChIP, IHC, WB, IHC-P, IF, ICC, IP
Konzentration:: 1.7 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: PBS, 20% Glycerol, 0.025% ProClin 300.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human TET1. The exact sequence is proprietary.
Klon:: N3C1
Uniprot:: Q8NFU7
Synonyme:: bA119F7.1;CXXC finger 6;CXXC zinc finger 6;CXXC-type zinc finger protein 6;CXXC6;LCX;leukemia-associated protein with a CXXC domain;methylcytosine dioxygenase TET1;ten-eleven translocation 1 gene protein;ten-eleven translocation-1;tet oncogene 1;TET1 splice variant VP_DE4;TET1 splice variant VP_DE456
Weitere Details:: Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.

Versandbedingungen:: Blue Ice