GTX12397
IGF2R antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX12397
- Anwendung:
- WB, IHC-P, IF, ICC
- Konzentration:
- 500 ug/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.1% Na₂HPO₄, 0.45% NaCl, 2.5% BSA, 0.025% Thimerosal, 0.025% Sodium azide.
- Immunogen:
- A synthetic peptide corresponding to a sequence at the C-terminus of human Mannose 6 Phosphate Receptor(Cation independent)(2475-2491aa TKLVSFHDDSDEDLLHI), different from the related rat and mouse sequences by one amino acid.
- Uniprot:
- P11717
- Synonyme:
- 300 kDa mannose 6-phosphate receptor;cation-independent mannose-6-phosphate receptor;CD222;CI Man-6-P receptor;CI-M6PR;CIMPR;IGF-II receptor;Insulin-like growth factor 2 receptor;insulin-like growth factor II receptor;M6P-R;M6P/IGF2 receptor;M6P/IGF2R;MPR 300;MPR1;MPR300;MPRI
- Weitere Details:
- This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
- Versandbedingungen:
- Blue Ice