GTX12191
PRMT5 antibody [PRMT5-21]
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX12191
- Zusätzliche Namen:
- protein arginine methyltransferase 5 , HRMT1L5 , HSL7 , IBP72 , JBP1 , SKB1 , SKB1Hs
- Anwendung:
- ELISA, WB
- Konzentration:
- 2 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Canine, Hamster, Human, Mouse, Rat
- Buffer:
- PBS, 15mM Sodium azide.
- Immunogen:
- GST-PRMT5 containing the C-terminal region of the human PRMT5 (amino acids 315-637).
- Klon:
- PRMT5-21
- Uniprot:
- O14744
- Synonyme:
- 72 kDa ICln-binding protein;histone-arginine N-methyltransferase PRMT5;HMT1 hnRNP methyltransferase-like 5;HRMT1L5;HSL7;IBP72;jak-binding protein 1;JBP1;protein arginine N-methyltransferase 5;shk1 kinase-binding protein 1 homolog;SKB1;SKB1 homolog;SKB1Hs
- Weitere Details:
- Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins (Histone 2A, 3, 4), IL enhancer binding factor, nuclear factors (NF45, 90, ILF3, Nucleolin, STAT1, Poly(A) binding protein II), cell cycle proteins (phosphoprotein phosphatase 2A), signal transduction proteins (FGF2, Fibrillarin, FN, INFAR1, Jak, MBP, Src-adaptor Sam68), apoptosis proteins (FADD, ICE-like protease), and viral proteins (Hepatitis C NS3 RNA Helicase, HIV TAR). The mammalian PRMT family currently consists of 5 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all five PRMT members have been developed. These antibodies can be utilized to explore arginine methylation and its regulatory functions.
- Versandbedingungen:
- Blue Ice