GTX12174
HDAC7 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX12174
- Zusätzliche Namen:
- histone deacetylase 7 , HD7 , HD7A , HDAC7A
- Anwendung:
- IHC, WB, IF, ICC, IP
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- synthetic peptide corresponding amino acids 436-452 of human HDAC7, conjugated to KLH.
- Uniprot:
- Q8WUI4
- Synonyme:
- HD7;HD7A;HDAC7A;histone deacetylase 7;histone deacetylase 7A
- Weitere Details:
- HDAC7 is a member of the class II mammalian histone deacetylases, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription.
- Versandbedingungen:
- Blue Ice