GTX12075
FOXO4 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX12075
- Zusätzliche Namen:
- forkhead box O4 , AFX , AFX1 , MLLT7
- Anwendung:
- WB, IF, ICC, IP
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 1% BSA, 15mM Sodium azide.
- Immunogen:
- synthetic peptide corresponding to the C-terminus of human AFX (amino acids 451-466) with N-terminally added lysine) conjugated to KLH.
- Uniprot:
- P98177
- Synonyme:
- AFX;AFX1;fork head domain transcription factor AFX1;forkhead box protein O4;MLLT7;myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
- Weitere Details:
- The forkhead family of transcription factors is involved in tumorigenesis in rhabdomyosarcoma and acute leukemias. Within the family, three members (FKHR, AFX and FKHRL1) have sequence similarity to the nematode homolog Daf 16, recently shown to mediate signaling via a pathway involving IGFR1, P13-K and Akt. There are three potential Akt phosphorylation sites on the FKHR proteins. One site, FKHR Ser256 is found in the Forkhead domain and the other two are outside this domain. Recent studies show that phosphorylation of FKHR family members by Akt promotes cell survival. Phosphorylation regulates FKHR nuclear translocation and target gene transcription. Insulin also stimulates FKHR phosphorylation at Ser253.
- Versandbedingungen:
- Blue Ice