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![p53 antibody [C2C3], C-term](https://www.genetex.com/upload/website/prouct_img/normal/GTX118730/GTX118730_40150_WB_HCT116 cisplatin_w_23060519_482.webp)
![p53 antibody [C2C3], C-term](https://www.genetex.com/upload/website/prouct_img/normal/GTX118730/GTX118730_40212_IHC_M_w_23060519_477.webp)
GTX118730
p53 antibody [C2C3], C-term
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX118730
- Zusätzliche Namen:
- tumor protein p53 , BCC7 , BMFS5 , LFS1 , P53 , TRP53
- Anwendung:
- WB, IHC-P, IP
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human p53. The exact sequence is proprietary.
- Klon:
- C2C3
- Uniprot:
- P04637
- Synonyme:
- antigen NY-CO-13;BCC7;BMFS5;cellular tumor antigen p53;LFS1;mutant tumor protein 53;P53;p53 tumor suppressor;phosphoprotein p53;transformation-related protein 53;TRP53;tumor protein 53;Tumor suppressor p53;tumor supressor p53
- Weitere Details:
- This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq]
- Versandbedingungen:
- Blue Ice