GTX117034
ERI1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX117034
- Zusätzliche Namen:
- exoribonuclease 1 , 3'HEXO , HEXO , THEX1
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human ERI1. The exact sequence is proprietary.
- Uniprot:
- Q8IV48
- Synonyme:
- 3' exoribonuclease;3'-5' exonuclease ERI1;3'-5' exoribonuclease 1;3'HEXO;enhanced RNAi three prime mRNA exonuclease homolog 1;Eri-1 homolog;HEXO;histone mRNA 3' end-specific exonuclease;histone mRNA 3'-end-specific exoribonuclease;histone mRNA 3'-exonuclease 1;Protein 3'hExo;THEX1;three prime histone mRNA exonuclease 1;three prime mRNA exonuclease 1
- Weitere Details:
- RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
- Versandbedingungen:
- Blue Ice