MMP24 antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX11649
Zusätzliche Namen:: matrix metallopeptidase 24 , AU040325 , MMP-21 , MT5-MMP , MT5MMP , MTMMP5
Anwendung:: ELISA, Flow Cytometry, WB, IHC-Fr, IP
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human, Mouse
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: PBS, 50% Glycerol, 15mM Sodium azide.
Immunogen:: synthetic peptide corresponding to the propeptide region of mouse matrix metalloproteinase-24 (membrane-type matrix metalloproteinase-5).
Uniprot:: Q9R0S2
Synonyme:: AU040325;matrix metalloproteinase-21;matrix metalloproteinase-24;membrane type 5-MMP;membrane-type matrix metalloproteinase 5;Membrane-type-5 matrix metalloproteinase;MMP-21;MT5-MM;MT5-MMP;MT5MMP;MTMMP5
Weitere Details:: Matrix Metalloproteinase 24 (MMP24, MT5MMP) has been described as a proteoglycanase, which is critical in the turnover of ECM (extracellular matrix) components in the brain. MMP24 contains a candidate signal sequence, a propeptide region, a potential furin recognition motif, a zinc-binding catalytic domain, a hemopexin-like domain, a 24-residue hydrophobic region, which acts as a potential transmembrane domain, and a short cytosolic domain. Unlike other MTMMPs, MMP24 (MT5MMP) sheds from the cell surface as soluble proteinases, allowing its versatility as both a cell bound and soluble proteinase in ECM remodeling processes. MMP24 is elevated in several tumor cell lines, and is also produced by some normal cell lines. It is predominantly expressed in the brain, indicating a role in nervous system development. MMP24 is also highly expressed during embryonic development. The mouse MMP24 gene maps to chromosome 2.

Versandbedingungen:: Blue Ice