RFWD3 antibody [C1C3]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX116292
Zusätzliche Namen:: ring finger and WD repeat domain 3 , FANCW , RNF201
Anwendung:: WB
Konzentration:: 0.96 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: 0.1M Tris, 0.1M Glycine, 20% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the C-terminus region of human RFWD3. The exact sequence is proprietary.
Klon:: C1C3
Uniprot:: Q6PCD5
Synonyme:: E3 ubiquitin-protein ligase RFWD3;FANCW;RING finger and WD repeat domain-containing protein 3;RING finger protein 201;RING-type E3 ubiquitin transferase RFWD3;RNF201
Weitere Details:: E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.