GTX11473
MAGI1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX11473
- Zusätzliche Namen:
- membrane associated guanylate kinase, WW and PDZ domain containing 1 , AIP-3 , AIP3 , BAIAP1 , BAP-1 , BAP1 , MAGI-1 , MAGI-1b , Magi1d , TNRC19 , WWP3
- Anwendung:
- WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Rat
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Rat
- Buffer:
- IgG fraction, no preservatives.
- Immunogen:
- synthetic peptide corresponding to amino acids 282-296 of MAGI-1 with a carboxy terminal added cysteine residue conjugated to maleimide-activated KLH. The sequence is conserved in human and mouse.
- Uniprot:
- Q96QZ7
- Synonyme:
- AIP-3;AIP3;atrophin-1-interacting protein 3;BAI1-associated protein 1;BAIAP1;BAP-1;BAP1;MAGI-1;MAGI-1b;Magi1d;membrane-associated guanylate kinase inverted 1;membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1;TNRC19;trinucleotide repeat-containing gene 19 protein;WW domain-containing protein 3;WWP3
- Weitere Details:
- The MAGUK (Membrane-Associated Guanylate Kinase) family of proteins is characterized by the presence of multi-PDZ and SH3 domains, and a single region of homology to Saccharomyces cerevisiae guanylate kinase (GuK) domain. All MAGUKs studied to date localize to regions of cell-cell contact such as tight junctions in epithelial cells and synaptic junctions in neurons and are believed to be involved in the assembly of multi-protein complexes via their protein-protein interaction domains. Three novel, closely related MAGUK proteins were isolated by means of different screening assays, and named MAGI1/BAP1, MAGI2/ S-SCAM /ARIP, and SLIPR/MAGI3. MAGI1 was first identified in mouse as a protein interacting with K-RasB. Three isoforms were identified, and named MAGI1a, MAGI1b, and MAGI1c, of 1139, 1171, and 1374 amino acids respectively. The isolation of a growing number of MAGI1 binding partners, together with the determination of the subcellular and tissue distribution of the different isoforms, are paving the way towards elucidation of its function.
- Versandbedingungen:
- Blue Ice