GTX113851
TCF7 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX113851
- Zusätzliche Namen:
- transcription factor 7 , TCF-1
- Anwendung:
- WB, IHC-P, IP
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 20% Glycerol, 0.01% Thimerosal.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human TCF7. The exact sequence is proprietary.
- Uniprot:
- P36402
- Synonyme:
- T-cell-factor-7;T-cell-specific transcription factor 1;TCF-1;transcription factor 7;transcription factor 7 (T-cell specific, HMG-box)
- Weitere Details:
- Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
- Versandbedingungen:
- Blue Ice