PSMA7 antibody [N1C2]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX113531
Zusätzliche Namen:: proteasome subunit alpha 7 , C6 , HEL-S-276 , HSPC , RC6-1 , XAPC7
Anwendung:: WB, IHC-P
Konzentration:: 0.86 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: 0.1M Tris, 0.1M Glycine, 20% Glycerol, 0.01% Thimerosal.
Immunogen:: Recombinant protein encompassing a sequence within the center region of human PSMA7. The exact sequence is proprietary.
Klon:: N1C2
Uniprot:: O14818
Synonyme:: C6;epididymis secretory protein Li 276;HEL-S-276;HSPC;proteasome (prosome, macropain) subunit, alpha type, 7;proteasome subunit alpha 4;proteasome subunit alpha 7;proteasome subunit alpha type-7;proteasome subunit RC6-1;proteasome subunit XAPC7;RC6-1;testicular tissue protein Li 151;XAPC7
Weitere Details:: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9. [provided by RefSeq]

Versandbedingungen:: Blue Ice